BendIocArBAmAte effect on the centrAl nervouS SyStem In the chIcK emBryo

The carbamate compounds are a class of cholinesterase-inhibiting pesticides (Farage-Elawar, 1990) and bendiocarb (2, 3-isopropyledene-dioxyphenyl methylcarbamate, BC) is the most widely used carbamate insecticide to control disease vectors (mosquitoes, flies, household and agricultural pests). Like other carbamate insecticides, BC is a reversible inhibitor of acetylcholinesterase (AChE). The blockage of AChE caused by BC persists for approximately 24 hours and, subsequently, the situation returns to normal because the insecticide does not accumulate in mammalian tissues (Siroťáková et al., 2005). However, concerning the exposure to BC it was observed that the substance can easily pass from mother to the developing embryo (Whyatt et al., 2003). Inhibition of AChE is linked with the pesticide mechanism of toxic action, irreversible or reversible bonding to the esteratic site of the enzyme and ABStrAct